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Proton Beam Therapy in Pediatric Oncology

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Proton beam therapy is a very accurate and focused type of radiation treatment that looks very hopeful in fighting childhood cancers.

Written by

Dr. Vineetha. V

Medically reviewed by

Dr. Muhammed Hassan

Published At February 6, 2024
Reviewed AtFebruary 23, 2024

Introduction

Finding out a child has cancer is very sad for both the child and their family. Even though doctors have made a lot of progress in treating kids with cancer, they are still trying to find better and gentler ways to help. Proton beam therapy, a special kind of radiation treatment that targets the cancer directly, is giving hope in this fight. This article explains how this treatment is used for kids with cancer, what it is good for, what's hard about it, and how it could make life better for these young patients.

What Is Proton Beam Therapy?

Proton beam therapy or proton therapy is a specialized and advanced form of radiation therapy used in the treatment of cancer. It distinguishes itself from traditional X-ray radiation therapy, which employs photons, by using high-energy protons to irradiate cancerous tissue. Proton therapy is often favored for treating certain types of cancer, such as pediatric tumors, eye tumors, and tumors located in proximity to vital organs, where the need to protect surrounding healthy tissues is critical. The approach is associated with several potential advantages, including reduced long-term side effects, an improved quality of life during and after treatment, and the potential for enhanced treatment outcomes.

The fundamental principle behind proton therapy lies in the unique physical properties of protons. Protons are positively charged particles, and their behavior in the human body is distinct from X-ray photons. Unlike photons, which release their energy both before and after reaching the target tumor, protons have the ability to release the majority of their energy at a specific depth within the body, known as the Bragg peak. This allows proton therapy to focus the radiation precisely on the tumor, minimizing the exposure of surrounding healthy tissues and organs to harmful radiation. The result is a reduced risk of collateral damage and potential side effects, which is particularly important when treating pediatric patients and other individuals with sensitive tissues.

What Can Children Expect During Proton Beam Therapy?

A typical course of proton therapy treatment lasts approximately six to eight weeks, involving daily weekday sessions lasting around 30 to 45 minutes. The majority of this time is dedicated to positioning the child accurately for the treatment. This therapy is a painless procedure that does not necessitate a hospital stay. Young children under the age of six might require general anesthesia to ensure they remain perfectly still throughout the treatment.

Which Types of Childhood Cancer Can Be Treated Using Proton Beam Therapy?

Some of the pediatric cancers that can be treated with PBT include:

  • Brain and Central Nervous System Tumors: PBT is effective for treating brain tumors in children, as it can precisely target the tumor while minimizing damage to healthy brain tissue. Brain tumors, such as glioma, medulloblastoma, ependymoma, germ cell tumor, and more, can be managed with the help of this therapy.

  • Eye Tumors: Ocular cancers like retinoblastoma and uveal melanoma can be treated with PBT. Preserving vision and ocular structures is crucial in pediatric cases.

  • Head and Neck Cancers: For cancers such as nasopharyngeal and parotid gland tumors and others), PBT is beneficial when tumors are located near critical structures like the spinal cord, salivary glands, and vocal cords. This helps in preserving essential functions like swallowing and speech.

  • Skull Base Tumors: Tumors in the skull base, where vital nerves and blood vessels are concentrated, can be effectively treated with PBT.

  • Prostate Cancer: In certain cases of pediatric prostate cancer, PBT can be considered to reduce the risk of side effects associated with conventional radiation therapy.

  • Spinal Cord Tumors: Tumors near the spinal cord or within the central nervous system can be treated with PBT to minimize neurological complications.

  • Recurrent Tumors: PBT can also be used for treating recurrent tumors, especially when a high radiation dose is required, and there's a need to minimize additional exposure to previously treated tissues.

  • Rare and Aggressive Cancers: PBT is a valuable option for treating rare and aggressive pediatric cancers where a targeted and precise approach is necessary.

What Are the Advantages of Proton Beam Therapy in Pediatric Oncology?

The advantages of Proton Beam Therapy in Pediatric Oncology are mentioned below:

1. Less Radiation Exposure -

Proton Beam Therapy (PBT) reduces the risk of exposing healthy tissues to radiation, which is crucial for children's sensitive bodies. This lowers the chances of long-term side effects, such as abnormal growth and secondary cancers.

2. Reduced Immediate Side Effects -

PBT minimizes immediate side effects during and after treatment, easing symptoms like nausea, fatigue, and pain. By protecting healthy tissues, PBT makes the treatment journey more manageable for young patients.

3. Improved Treatment Results -

The precise nature of PBT enables more aggressive treatment of pediatric tumors, leading to better outcomes, higher chances of long-term remission, or even a complete cure. It is particularly effective for tumors in sensitive areas like the brain.

4. Rare Cancer Management -

PBT provides a valuable option for treating rare pediatric cancers that have limited standard treatment choices. Its targeted approach is beneficial for complex and uncommon cases.

5. Reduced Risk of Cognitive Issues -

When treating brain tumors in children, preserving cognitive development is crucial. PBT's ability to protect healthy brain tissue reduces the risk of cognitive impairment, ensuring a better quality of life for the child.

6. Enhanced Quality of Life -

PBT aims to enhance the overall quality of life for children with cancer. By minimizing radiation-related side effects and preserving essential functions and growth, it helps children not only survive cancer but thrive post-treatment.

7. Eye Tumor Care -

PBT is especially valuable for eye tumors like retinoblastoma. Its precision helps preserve vision and maintain the eye's critical structures, which is vital for a child's overall development.

8. Lower Long-Term Risks -

By reducing radiation exposure, PBT decreases the likelihood of developing secondary cancers later in life, a crucial concern for pediatric cancer survivors with a long life expectancy.

Do Proton Therapy Treatments Carry Any Risks for Pediatric Patients?

Proton therapy stands out as an excellent choice for treating certain childhood cancers due to its exceptional precision in targeting cancer cells. This precision reduces harm to healthy and developing cells, resulting in fewer side effects. Moreover, the risk of long-term side effects, like learning disabilities, hearing loss, and other issues, is minimized. When side effects occur during therapy, they are generally mild. These side effects can include fatigue, skin irritation, and hair loss at the treatment site.

Conclusion

Doctors often use surgery, chemotherapy, and radiation therapy to treat most tumors in children. Regular radiation therapy using X-ray beams can work, but it can also cause some long-term problems for a few kids. These problems include issues with bone and soft tissue growth, hormone problems, trouble with thinking, like learning difficulties, and sometimes even more cancer later in life. Proton therapy is a big step forward in treating children with cancer. It can hit the tumor right on target while keeping its healthy parts safe. As scientists learn more and the technology gets better, proton beam therapy could become a regular treatment for pediatric patients with cancer. The goal of this therapy is to make it easier to get, cost less, and work even better. That way, every child has a better chance of beating cancer.

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Dr. Muhammed Hassan
Dr. Muhammed Hassan

Internal Medicine

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