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Infectious Causes of Cancer

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Infections with specific viruses, bacteria, and parasites have been linked to several types of cancer in humans. Read the article to know more.

Medically reviewed by

Dr. Rajesh Gulati

Published At May 18, 2023
Reviewed AtMay 18, 2023

Introduction:

It is well known that certain infections can increase the risk of developing certain types of cancer. This includes viruses, bacteria, and even parasites. Viruses like HPV (human papillomavirus), hepatitis B, and Epstein-Barr virus can lead to various types of cancer. Bacteria such as Helicobacter pylori and Salmonella can also contribute to cancer. Even some parasites, like schistosomiasis, have been linked to cancer. By understanding how infections cause cancer, we can take steps to prevent them and reduce our risk of cancer. Certain preventive measures such as vaccinations, antibiotics, and parasite control can all help reduce the risk of developing cancer from an infection.

What Are the Most Common Infections That Can Lead to Cancer?

Several infections have been linked to an increased risk of developing cancer. These include infections with certain viruses and bacteria, as well as parasites.

What Viruses Can Cause Cancer?

Viruses that can cause cancer include the human papillomavirus (HPV), hepatitis B and C viruses, Epstein-Barr virus, and the human T-cell lymphotropic virus type 1. HPV is the most common virus linked to cancer, and it is associated with cervical, anal, vaginal, vulvar, penile, and oropharyngeal cancers.

  • Human Papillomavirus (HPV): Human papillomavirus (HPV) is a virus that can cause infections and is the most common cause of cancer. HPV infection is linked to several types of cancer including cervical, anal, and oral cancer. The virus can be spread through direct skin-to-skin contact, sexual contact, and even through touching objects that have been in contact with the virus. To prevent HPV infections, it is important to practice safe sex by using condoms and abstaining from sexual activities with multiple partners. It is also recommended to get vaccinated against HPV if the individual is between the ages of 9 to 26 years old. Vaccination helps reduce the risk of infection and developing cancer later on. Early detection and treatment of infections can help reduce the risk of developing cancer in the future.
  • Hepatitis B Virus and Hepatitis C Virus (HBV and HIV): Hepatitis B and C are two of the most common viruses that can lead to cancer. Hepatitis B is a contagious liver infection caused by the Hepatitis B virus. It can cause serious damage to the liver, including cirrhosis and even liver cancer. The virus can be transmitted through contact with infected blood, semen, or other body fluids, as well as from mother to child during childbirth.

Hepatitis C is a contagious liver disease caused by the Hepatitis C virus (HCV). It is the leading cause of liver cancer, and it is estimated that around 71 million people have chronic HCV infection. It is spread by coming into contact with infected blood, usually through sharing needles or other drug-related equipment.

There is no cure for either HBV or HCV, but it is possible to manage the symptoms and minimize the risk of developing cancer. Treatment options include antiviral medications, which can reduce the risk of complications and cancer in some cases. Vaccines are also available for both hepatitis B and C, and these can help prevent infection. Finally, practicing safe sex and avoiding contact with infected blood is the best way to protect from both viruses.

  • Epstein - Barr Virus (EBV): Epstein-Barr Virus (EBV) is a virus that belongs to the family of herpes viruses. It is one of the most common human viruses, infecting more than 90 percent of adults worldwide. EBV is most commonly associated with mononucleosis, but it can also be linked to other health issues, including certain types of cancer.

EBV infections are generally asymptomatic or mild and can go unnoticed. When symptoms do occur, they usually include fever, fatigue, sore throat, swollen lymph nodes, and enlarged spleen. EBV can be transmitted through saliva and is spread mainly by kissing and other close contacts. It can also be transmitted through blood, organ transplants, and sexual contact.

Certain types of cancers have been linked to EBV, including Hodgkin's lymphoma, Burkitt's lymphoma, nasopharyngeal carcinoma (a type of head and neck cancer), and stomach cancer. It is important to note that not everyone who is infected with EBV will develop cancer; however, those who do are at an increased risk.

To protect from EBV infection, it is essential to practice good hygiene habits such as washing hands regularly, avoiding kissing people with an active infection, and practicing safe sex.

What Bacteria Can Cause Cancer?

Bacteria that can lead to cancer include Helicobacter pylori, which is associated with stomach cancer; Chlamydia trachomatis, which is associated with cervical cancer; and Treponema pallidum, which is linked to liver cancer.

  • Helicobacter Pylori: Helicobacter pylori (H. pylori) is a type of bacteria that can cause chronic infection in the stomach and small intestine and is linked to certain types of cancer. H. pylori infection has been linked to an increased risk for both stomach and esophageal cancer. The infection may also contribute to lymphomas, a type of cancer that begins in the immune system, as well as other cancers such as liver cancer, pancreatic cancer, and colorectal cancer.

H. pylori can be spread from person to person through contact with saliva, vomit, or fecal matter, which may happen when people do not practice good hygiene. While the infection may not cause symptoms in some cases, it can cause gastritis (inflammation of the stomach lining), ulcers, indigestion, and abdominal pain.

To protect from H. pylori infections, wash hands often and practice proper hygiene, avoid sharing utensils or other items with someone infected, and ensure food is cooked properly before eating it. Treatment options include antibiotics, bismuth-based drugs, and proton pump inhibitors.

  • Chlamydia Trachomatis: Chlamydia trachomatis is a type of bacteria that can cause infections and lead to cancer, most commonly cervical cancer. This bacteria is spread through sexual contact and is the most commonly reported bacterial sexually transmitted infection in the United States. It can also be spread from an infected mother to her baby during childbirth. If left untreated, it can lead to serious health issues such as infertility, pelvic inflammatory disease, and in rare cases, even cancer.
  • Treponema: Treponema is a genus of bacteria that includes several species that are associated with causing various diseases in humans, such as syphilis and yaws. Some Treponema species have been linked to an increased risk of developing certain types of cancer, most notably gastric cancer.

What Parasites Can Cause Cancer?

Opisthorchis viverrini and Schistosoma haematobium are liver flukes (a type of flatworm) that have been associated with increased risk for bile duct cancer and bladder cancer, respectively. The chances of developing cancer from an infection depend on many factors, including overall health and lifestyle. However, knowing about the infections that can lead to cancer can help to take steps to reduce the risk.

  • Opisthorchis: Opisthorchis viverrini is a type of parasitic worm that is found in the digestive tracts of fish-eating mammals. It is primarily spread through the consumption of raw or undercooked fish and can lead to infection. If left untreated, infection with this parasite can cause inflammation in the bile ducts, leading to cholangiocarcinoma (bile duct cancer). To prevent infection with Opisthorchis viverrini, it is recommended to thoroughly cook all fish before consumption, as well as take preventive measures against parasites in general.
  • Schistosoma Haematobium Is a species of parasitic worm that can cause schistosomiasis, a disease that has been linked to an increased risk of bladder cancer. It is usually spread through contact with contaminated surfaces, freshwater, or soil and its symptoms can include blood in the urine, stomach pain, and fever. To protect from Schistosoma haematobium, it is important to avoid swimming or bathing in any water sources that are not sure it is clean and safe. Additionally, wearing protective footwear when walking in potentially contaminated areas can help reduce the risk of infection. Treatment for those infected with Schistosoma haematobium includes medication, depending on the severity of the infection.

Conclusion

It is important to be aware that certain infections can lead to cancer. Viruses such as the HPV virus, hepatitis B and C viruses, Epstein-Barr virus, and Helicobacter pylori, as well as a parasitic worm called Schistosoma haematobium, can all increase the risk of developing cancer. To protect from these infections, it is important to practice safe sex, get vaccinated against certain viruses, use protection when swimming in areas where Schistosoma haematobium is found, and practice good hygiene habits. Furthermore, it is important to maintain a healthy lifestyle by getting regular check-ups, eating a balanced diet, exercising, and avoiding smoking and excessive drinking. By following these steps, a person can reduce the risk of developing cancer due to infection.

Dr. K. M. Tarannum
Dr. K. M. Tarannum

Dentistry

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